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Observe Closely (two)istradefylline will raise the degree or influence of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.indinavir will boost the degree or effect of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Avoid coadministration of pazopanib with robust CYP3A4